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 Regularly evaluate sufferers with a heritage of seizure disorders for worsened seizure Regulate throughout DEMEROL Tablets and Oral Option therapy. Use of DEMEROL Tablets and Oral Option for an extended length of time could boost the hazard of toxicity (e.g., seizures) with the accumulation from the meperidine metabolite, normeperidine. In

The concomitant utilization of DEMEROL Tablets or Oral Solution and CYP3A4 or CYP2B6 inducers can reduce the plasma concentration of meperidine [see Scientific Pharmacology (12.three)], causing diminished efficacy or onset of the withdrawal syndrome in patients who've created Bodily dependence to meperidine [see Warnings and Safeguards (5.

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